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Department of Medical and Surgical Sciences

Cytogenetics Laboratory

The activity is focused on conventional and molecular cytogenetic analyses, aimed at identifying and characterizing oncohaematological diseases such as: Acute Lymphoid Leukemias, Acute Myeloid Leukemias, Chronic Lymphocytic Leukemia, Chronic Myeloid Leukemia, Multiple Myeloma and Myelodysplastic Syndrome.

Areas: Oncology and Haematology

Research Projects:

Cytogenetic-molecular characterization related to:

  • Cytogenetic diagnoses of oncohematological diseases.
  • Identification of prognostic risk factors.
  • Support for clinical trials and translational studies for:
  • Multiple myeloma
  • Acute and chronic, myeloid and lymphoid syndromes
  • Myelodysplastic syndromes
  • Study of cytogenetic markers and their molecular characteristics related to their prognostic and therapeutic implications.
  • Progetto di Ricerca Finalizzata 2018, Italian Ministry of Health - Young Researchers: “High risk genetic abnormalities in Acute Myeloid Leukemia and Myelodisplastic Syndrome: unravelling the pathogenetic mechanisms to improve diagnostic and therapeutic approaches”; PI Dott.ssa Carmen Baldazzi.

 

Academic activity:

  • Oncohematological Genetics - School of Medicine and Surgery.
  • Teaching: Anemias; Cytology; Cytogenetics; Hematological Diagnostic - School of Specialization in Hematology.
  • Tutor of students for Internships – Master’s Degree in Health Biology and Biotechnology.
  • Tutor of students for Internships - Degree in Biomedical Laboratory Technician.

 

Equipment:

  • 3 Hybrite (Vysis) for molecular cytogenetics.
  • system of 3 image analyzers for cytogenetics and FISH connected to 3 optical and fluorescent microscopes (Nikon, Genikon).
  • system for automated FISH scanning and analysis connected to a fluorescent microscope (Olympus, Bioview).
  • 2 centrifuges.
  • incubator for cell cultures.
  • 2 optical microscopes (Zeiss).
  • chemical hood.
  • laminar flow hood.

Responsabile

Team

Giulia Marzocchi

Area dei Funzionari - Settore scientifico - tecnologico

Collaborators

Dr. Carmen Baldazzi Biotechnologist, PhD

Dr. Simona Luatti Biologist, PhD

Dr. Alessandra Grassi Biotechnologist

Mrs. Gloria Caroli Laboratory technician

Cristina Mecucci - Hematology and Bone Marrow Transplantation Unit, Department of Medicine, Molecular Medicine Laboratory, University of Perugia, Italy.

Anna Valenti - Medical Genetics Unique Laboratory, Pievesistina (FC), Italy.

Giovanni Martinelli: Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola (FC), Italy.

Piera Versura: Ophthalmology Unit, University of Bologna and S. Orsola-Malpighi Teaching Hospital, Bologna, Italy.

National Centre for Rare Diseases Higher Institute of Health.

GIMEMA (Italian Group of Hematological Diseases of the Adult).

Laboratory location

Istituto di Ematologia “L. e A. Seragnoli”, DIMES

IRCCS Azienda Ospedaliera Universitaria di Bologna