Obstructive Sleep Apnea Syndrome - OSAS
This research group is dedicated to the study of obstructive sleep apnea syndrome (OSAS), both in pediatric and adult patients. This is a life-threatening disease with a very high disease rate of 3–7% in the general population, with a number of anatomical abnormalities and neuromuscular dysfunctions that lead to repeated episodes of partial or complete airway obstruction during sleep. OSAS is associated with significant morbidity, such as cardiovascular and metabolic diseases, daytime hypersomnolence, neurocognitive deficits, and reduced quality of life. The role of the ENT head and neck surgeon is fundamental for classifying patients correctly and offering the most appropriate treatment options.
Research areas
Study of the causes of OSAS; instrumental investigations and surgical treatments of the pediatric and adult OSAS patient.
Research projects
- definition of the causes and mechanisms underlying the collapse of the airway in OSAS patients;
- definition of anatomical and polysomnographic features for the phenotypic classification of the OSAS patient;
- study of the implementation of sleep endoscopy ("Advanced sleep endoscopy") in order to improve the sensitivity of the diagnosis and to correctly classify the patient’s OSAS phenotype, for an appropriate personalized therapy;
- study of the anatomical and functional results of oropharyngeal surgery in the OSAS patient, in particular of lateral expansive pharyngoplasty with barbed suture (barbed-functional expansion pharyngoplasty).
Ongoing research objectives
- Ippolito DR, Stipa C, Cameli M, Sorrenti G, Pelligra I, Alessandri-Bonetti G. Maximum voluntary retrusion or habitual bite position for mandibular advancement assessment in the treatment of obstructive sleep apnoea patients. J Oral Rehabil. 2020 Mar;47(3):301-306. doi: 10.1111/joor.12902. Epub 2019 Nov 21. PMID: 31698516.
- Sorrenti G, Pelligra I, Albertini R, Caccamo G, Piccin O. Functional expansion pharyngoplasty: Technical update by unidirectional barbed sutures. Clin Otolaryngol. 2018 Oct;43(5):1419-1421. doi: 10.1111/coa.13105. Epub 2018 Apr 16. PMID: 29575572.
- Stipa C, Cameli M, Sorrenti G, Ippolito DR, Pelligra I, Alessandri-Bonetti G. Relationship between cephalometric parameters and the apnoea-hypopnoea index in OSA patients: a retrospective cohort study. Eur J Orthod. 2020 Jan 27;42(1):101-106. doi: 10.1093/ejo/cjz038. PMID: 31143924.
- Piccin O, Sorrenti G, Farneti P, Cioccoloni E, Burgio L. Ultrasonographic assessment of tonsillar volume in children. Int J Pediatr Otorhinolaryngol. 2017 Oct;101:262. doi: 10.1016/j.ijporl.2017.08.003. Epub 2017 Aug 4. PMID: 28802748.
- De Vito A, Carrasco Llatas M, Vanni A, Bosi M, Braghiroli A, Campanini A, de Vries N, Hamans E, Hohenhorst W, Kotecha BT, Maurer J, Montevecchi F, Piccin O, Sorrenti G, Vanderveken OM, Vicini C. European position paper on drug-induced sedation endoscopy (DISE). Sleep Breath. 2014 Sep;18(3):453-65. doi: 10.1007/s11325-014-0989-6. Epub 2014 May 26. PMID: 24859484.
- Baiardi S, Gobbi R, Sorrenti G. An Objective Drug-Induced Sedation Endoscopy Data Capture and Analysis System-Reply. JAMA Otolaryngol Head Neck Surg. 2017 Sep 1;143(9):959-960. doi: 10.1001/jamaoto.2017.0670. PMID: 28654936.
- Sorrenti G, Piccin O. Functional expansion pharyngoplasty in the treatment of obstructive sleep apnea. Laryngoscope. 2013 Nov;123(11):2905-8. doi: 10.1002/lary.23911. Epub 2013 Jul 10. PMID: 23842843.
- Sorrenti G, Piccin O, Mondini S, Ceroni AR. One-phase management of severe obstructive sleep apnea: tongue base reduction with hyoepiglottoplasty plus uvulopalatopharyngoplasty. Otolaryngol Head Neck Surg. 2006 Dec;135(6):906-10. doi: 10.1016/j.otohns.2006.06.1253. PMID: 17141082.
- Linee guida in Roncochirurgia ORL – Argomenti di Acta otorhinolaryngologica Italica – Organo Ufficiale della Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale.
HEAD OF RESEARCH GROUP
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Dr. Giovanni Sorrenti
TEAM
Collaborators
Dott.ssa Irene Pelligra, team member