Transglutaminase in matrix remodelling and kidney fibrosis

Contatto di riferimento: Prof.ssa Elisabetta Verderio

Partecipanti: Prof.ssa Elisabetta Verderio (Dipartimento di Scienze Biologiche, Geologiche e Ambientali)

A dynamic network of molecules in our bodies, the extracellular matrix (ECM) continuously changes and remodels to maintain normal cell function. Without ECM, anchorage-dependent cells would die, but with too much fibrous matrix cells would not survive. This matrix repairs and heals, however if an injury persists it accumulates in vast amounts leading to extreme scarring and cell death. This talk will reveal what we have learned about a chief factor that allows the matrix to transform and re-invent itself, type 2-transglutaminase, and the importance