Endocrinologia

Responsabile scientifico/Coordinatore - Prof. Uberto Pagotto

Attività scientifica

The research team operates in the Clinical Units ofEndocrinologyand Diabetesin the University General Hospital.

Personnel:12 among staff endocrinologists and diabetologists, 6 fellows MD, 11 residents, 12 nurses, 2 dietitians, 1 psychologist, 3 medical biotechnologists.

Clinical facility: 20 rooms for medical examinations, 6 rooms for blood withdrawal, diagnostic tests and treatments, 1 room specifically assigned to clinical trials.

Databaseof the Units includes records of 59000 patients affected by all types of endocrine and metabolic diseases, plus 28000 type-2-diabetes patients. Up to 12000 and 9000 visits/year are usually performed by the Endocrinology and Diabetes Units, respectively.

Laboratory facility: located at the Center for Applied Biomedical Research, it mainly includes liquid chromatography tandem mass spectrometry (LC-MS/MS) platform (4000Q-Trap, AB Sciex), 4 rooms for bench-working, instrument location and data analysis. Biobank storage facility. Seven in house assays and one commercial assay for small molecules and hormones (metabolomics panel, steroids, endocannabinoids) quantitation in biologic fluids (serum, plasma, saliva, cell culture, tissues, faeces extracts). >50000 samples analyzed in ten years.

Research areas:

  • Clinic/translational research in humans
  • Obesity and Dysmetabolism
  • Endocannabinoid System
  • Female hyperandrogenism and Polycystic Ovary Syndrome
  • Lipodystrophy
  • Male hypogonadism
  • Non Classic - Congenital Adrenal Hyperplasia
  • Adrenal tumors and subclinical glucocorticoid excess
  • Pituitary tumors
  • Cushing’s Syndrome
  • Diabetes
  • Secondary/resistant hypertension
  • Rare diseases (Turner, Prader Willi)

Membri del gruppo

Paola Altieri

Ricercatrice confermata

Guido Di Dalmazi

Ricercatore a tempo determinato tipo b) (senior)

Flaminia Fanelli

Ricercatrice a tempo determinato tipo b) (senior)

Alessandra Gambineri

Professoressa associata

Uberto Pagotto

Professore ordinario

Carla Pelusi

Ricercatrice confermata

Valentina Vicennati

Professoressa associata

Collaborazioni nazionali e internazionali 

  • HarmoSter - Consortium for the harmonization of steroid hormone measurements: Vogeser M, Institute for Laboratory Medicine, Ludwig Maximilians University Hospital, Munich Germany; Eisenhofer G, Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Rauh M, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen Germany; Keevil BGDepartment of Clinical Biochemistry, University Hospital South Manchester, Manchester, United Kingdom; Heijboer A Department of Clinical Chemistry, VUmc-AMC University Hospital, Amsterdam, The Netherlands; Van den Ouweland J, Department of Clinical Chemistry, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; Bruce S, Clinical Chemistry Laboratory, Lausanne University Hospital CHUV, Lausanne, Switzerland; Cantù M, Department of Laboratory Medicine EOLAB, Laboratory of Clinical Biochemistry & Pharmacology, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Herrmann M, Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Koal T, BIOCRATES Life Sciences AG, Innsbruck, Austria
  • Tissue metabolomics in adrenocortical tumors: Felix Beuschlein, University of Zurich; Alex Walch, Helmholtz Zentrum München; Martin Reincke, Ludwig Maximilian University Munich; Martin Fassnacht, University of Wurzburg.
  • RNA-sequencing in adrenocortical tumors: Cristina Ronchi, University of Brimingham; Felix Beuschlein, University of Zurich; Martin Reincke, Ludwig Maximilian University Munich; Martin Fassnacht, University of Wurzburg.
  • Long-term outcomes of adrenocortical tumors: Felix Beuschlein, University of Zurich; Martin Reincke, Ludwig Maximilian University Munich; Martin Fassnacht, University of Wurzburg; ENSAT.
  • Urinary steroid profile in adrenal Cushing syndrome: Martin Reincke, Ludwig Maximilian University Munich.
  • European Consortium of Lipodystrophies, ECLip: Martin Wabitsch, Germany; Corinne Vigouroux, France; Ferruccio Santini, Italy; Bari Akinci, Turkey; David Araùjo-Vilar, Spain
  • @OBEDIS funded by the JPI HDHL (Joint Programming Initiative a Healthy Diet for a Healthy Life, an European network ‘Guidelines for Obesity Dietary Interventions

Produzione scientifica

  1. Di Dalmazi G, Fanelli F, Zavatta G, Ricci Bitti S, Mezzullo M, Repaci A, Pelusi C, Gambineri A, Altieri P, Mosconi C, Balacchi C, Golfieri R, Cosentino ER, Borghi C, Vicennati V, Pasquali R, Pagotto U. The Steroid Profile of Adrenal Incidentalomas: Subtyping Subjects With High Cardiovascular Risk. J Clin Endocrinol Metab. 2019;104:5519-5528.
  2. Di Dalmazi G, Timmers HJLM, Arnaldi G, Küsters B, Scarpelli M, Bathon K, Calebiro D, Beuschlein F, Hermus A, Reincke M. Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome. J Clin Endocrinol Metab. 2019 Jul 5. pii: jc.2018-02209. doi: 10.1210/jc.2018-02209. [Epub ahead of print]
  3. Eisenhofer G, Masjkur J, Peitzsch M, Di Dalmazi G, Bidlingmaier M, Grüber M, Fazel J, Osswald A, Beuschlein F, Reincke M. Plasma Steroid Metabolome Profiling for Diagnosis and Subtyping Patients with Cushing Syndrome. Clin Chem. 2018 ;64:586-596.
  4. Ronchi CL, Di Dalmazi G, Faillot S, Sbiera S, Assié G, Weigand I, Calebiro D, Schwarzmayr T, Appenzeller S, Rubin B, Waldmann J, Scaroni C, Bartsch DK, Mantero F, Mannelli M, Kastelan D, Chiodini I, Bertherat J, Reincke M, Strom TM, Fassnacht M, Beuschlein F; European Network for the Study of Adrenocortical Tumors (ENSAT). Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation. J Clin Endocrinol Metab. 2016;101:3526-38.
  5. Di Dalmazi G, Kisker C, Calebiro D, Mannelli M, Canu L, Arnaldi G, Quinkler M, Rayes N, Tabarin A, Laure Jullié M, Mantero F, Rubin B, Waldmann J, Bartsch DK, Pasquali R, Lohse M, Allolio B, Fassnacht M, Beuschlein F, Reincke M. Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. J Clin Endocrinol Metab. 2014; 99:2093-00
  6. Di Dalmazi G, Vicennati V, Garelli S, Casadio E, Rinaldi E, Giampalma E, Mosconi C, Golfieri R, Paccapelo A, Pagotto U, Pasquali R. Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing's syndrome: a 15-year retrospective study. Lancet Diabetes Endocrinol. 2014;2:396-405.
  7. Pellegrini C, Columbaro M, Schena E, Prencipe S, Andrenacci D, Iozzo P, Angela Guzzardi M, Capanni C, Mattioli E, Loi M, Araujo-Vilar D, Squarzoni S, Cinti S, Morselli P, Giorgetti A, Zanotti L, Gambineri A, Lattanzi G. Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Exp Mol Med. 2019 ;51:89.
  8. Mezzullo M, Fanelli F, Di Dalmazi G, Fazzini A, Ibarra-Gasparini D,Mastroroberto M, Guidi J, Morselli-Labate AM, Pasquali R, Pagotto U, Gambineri A. Salivary cortisol and cortisone responses to short-term psychological stress challenge in late adolescent and young women with different hyperandrogenic states. Psychoneuroendocrinology. 2018 ; 91:31-40.
  9. Ibáñez L, Oberfield SE, Witchel S, Auchus RJ, Chang RJ, Codner E, Dabadghao P, Darendeliler F, Elbarbary NS, Gambineri A, Garcia Rudaz C, Hoeger KM, López-Bermejo A, Ong K, Peña AS, Reinehr T, Santoro N, Tena-Sempere M, Tao R, Yildiz BO, Alkhayyat H, Deeb A, Joel D, Horikawa R, de Zegher F, Lee PA. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence. Horm Res Paediatr. 2017;88:371-395.
  10. Fanelli F, Mezzullo M, Repaci A, Belluomo I, Ibarra Gasparini D, Di Dalmazi G, Mastroroberto M, Vicennati V, Gambineri A, Morselli-Labate AM, Pasquali R, Pagotto U. Profiling plasma N-Acylethanolamine levels and their ratios as a biomarker of obesity and dysmetabolism. Mol Metab. 2018 14:82-94.
  11. Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B Adipocyte cannabinoidi receptor CB1 regulates energy homeostatsis and alternatively activated macrophages. J Clin Invest. 2017 Nov 1;127(11):4148-4162.