Medicina dell’età Prenatale

Responsabile scientifico/Coordinatore - Prof. Antonio Farina

Attività scientifica

  • Screening delle cardiopatie congenite mediante dosaggio molecolare di mRNA circolanti nel sangue della madre a partire da 20 settimane di gravidanza
  • Analisi dei profili di espressione di mRNA sui tessuti residui di villi coriali per la diagnosi precoce di preeclampsia

Membri del gruppo

Antonio Farina

Professore associato

Nicola Rizzo

Professore Alma Mater

Altri membri

Alessandra Curti

Dalila Bernabini

Cristina Lapucci (SynLab)

Silvia Berto (SynLab)

Andrea Fabbri (SynLab)

Tullia Todros (Università di Torino)

Federico Prefumo (Università di Brescia)

Collaborazioni internazionali

Prof. Akihiko Sekizawa, Showa University Tokyo

Prof. Dong Yun Cha, Cha Hospital, Seoul, Korea

Produzione scientifica

1. Cro' F, Lapucci C, Vicari E, Salsi G, Rizzo N, Farina A. An innovative test for non-invasive Kell genotyping on circulating fetal DNA by means of the allelic discrimination of K1 and K2 antigens. Am J Reprod Immunol. 2016 Dec;76(6):499-503. doi: 10.1111/aji.12593. Epub 2016 Oct 11. PubMed PMID: 27730708.

2. Curti A, Lapucci C, Berto S, Prandstraller D, Perolo A, Rizzo N, Farina A. Maternal plasma mRNA species in fetal heart defects: a potential for molecular screening. Prenat Diagn. 2016 Aug;36(8):738-43. doi: 10.1002/pd.4853. Epub 2016 Jul 4. PubMed PMID: 27257136.

3. Curti A, Zucchini C, De Maggio I, Ismail YS, Morano D, Falcone V, Meriggiola MC, Farina A. Fetal cardiac defects and third-trimester maternal serum placental growth factor. Ultrasound Obstet Gynecol. 2015 Jun;45(6):751-2. doi: 10.1002/uog.14748. Epub 2015 May 11. PubMed PMID: 25488892.

4. Zanello M, Sekizawa A, Purwosunu Y, Curti A, Farina A. Circulating mRNA for the PLAC1 gene as a second trimester marker (14-18 weeks' gestation) in the screening for late preeclampsia. Fetal Diagn Ther. 2014;36(3):196-201. doi: 10.1159/000360854. Epub 2014 Aug 15. PubMed PMID: 25138310.

5. Farina A, Arcelli D. Congenital heart defects: is it time to explore maternal blood for a non-invasive genetic screening test? Ultrasound Obstet Gynecol. 2014  Jan;43(1):109-10. doi: 10.1002/uog.13259. PubMed PMID: 24265201.

6. Zanello M, DeSanctis P, Pula G, Zucchini C, Pittalis MC, Rizzo N, Farina A. Circulating mRNA for epidermal growth factor-like domain 7 (EGFL7) in maternal blood and early intrauterine growth restriction. A preliminary analysis. Prenat Diagn. 2013 Feb;33(2):168-72. doi: 10.1002/pd.4034. Epub 2012 Dec 26. PubMed PMID: 23280513.

7. Farina A, Zucchini C, De Sanctis P, Morano D, Sekizawa A, Purwosunu Y, Okai T, Rizzo N. Gene expression in chorionic villous samples at 11 weeks of gestation in women who develop pre-eclampsia later in pregnancy: implications for screening. Prenat Diagn. 2011 Feb;31(2):181-5. doi: 10.1002/pd.2675. Epub 2011 Jan 4. PubMed PMID: 21268038.

8. Farina A, Zucchini C, Sekizawa A, Purwosunu Y, de Sanctis P, Santarsiero G, Rizzo N, Morano D, Okai T. Performance of messenger RNAs circulating in maternal  blood in the prediction of preeclampsia at 10-14 weeks. Am J Obstet Gynecol. 2010 Dec;203(6):575.e1-7. doi: 10.1016/j.ajog.2010.07.043. PubMed PMID: 20934680.

9. Lee KJ, Shim SH, Kang KM, Kang JH, Park DY, Kim SH, Farina A, Shim SS, Cha DH. Global gene expression changes induced in the human placenta during labor. Placenta. 2010 Aug;31(8):698-704. doi: 10.1016/j.placenta.2010.05.006. Epub 2010 Jun 15. PubMed PMID: 20554320.

10. Arcelli D, Farina A, Cappuzzello C, Bresin A, De Sanctis P, Perolo A, Prandstraller D, Valentini D, Zucchini C, Priori S, Rizzo N. Identification of circulating placental mRNA in maternal blood of pregnancies affected with fetal congenital heart diseases at the second trimester of pregnancy: implications for early molecular screening. Prenat Diagn. 2010 Mar;30(3):229-34. doi: 10.1002/pd.2443. PubMed PMID: 20063376.

11. Kang JH, Song H, Yoon JA, Park DY, Kim SH, Lee KJ, Farina A, Cho YK, Kim YN,  Park SW, Kim GJ, Shim SH, Cha DH. Preeclampsia leads to dysregulation of various signaling pathways in placenta. J Hypertens. 2011 May;29(5):928-36. doi: 10.1097/HJH.0b013e328344a82c. PubMed PMID: 21430563.